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Rizatriptan ods and its affect on Migraine

Even after years of research, Migraine remains to be an incurable disorder – no treatment can make patients free of migraine permanently.

People suffering from migraines can keep their condition in control by avoiding triggers that cause migraine. Identifying these triggers and working towards making little changes in lifestyle like easing stress and having good sleep habits can help curb the symptoms.

Prompt action and timely treatment help patients return to their normal routine, decreasing the need for pain medication.

Having said that, there are medications that help prevent or stop migraines, keeping the symptoms from getting worse. Rizatriptan is one such medication.

What is Rizatriptan?
Rizatriptan is a medication that’s used to treat migraines. It belongs to a class of drugs known as triptans and helps relieve headache, pain, and other migraine symptoms caused due to nausea, vomiting, and sensitivity to light/sound.

It affects a certain natural substance (serotonin) that causes the narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain.

Understanding Migraine & its effects on the brain
Migraine is a chronic neurological disorder characterized by recurrent headaches that range from moderate to severe, often in association with a number of autonomic nervous system symptoms.

Approximately 15% of the world population is affected by migraine at some point in life. In basilar migraine, a patient will experience neurological symptoms related to the brain stem or with neurological symptoms on both sides of the body. Some common effects of this migraine include a sense of the world spinning, light-headedness, and confusion. Nausea occurs in almost 90% of people, and vomiting occurs in about one-third.

Other symptoms may include blurred vision, nasal stuffiness, diarrhea, frequent urination, pallor, or sweating. Moreover, swelling or tenderness of the scalp may occur as well as neck stiffness. Oftentimes, a feeling of pins-and-needles begins on one side in the hand and arm and spreads to the nose-mouth area on the same side. Numbness usually occurs after the tingling has passed, with a loss of position sense.

As Rizatriptan is an Oral Thin Film (also called Orally Dissolving Film), it becomes extremely convenient for the patient to take the required prescribed dosage even when suffering from such severe symptoms. It’s also very easy to carry and needs no water, unlike solid oral dosage – a patient can put this film in their mouth anywhere, anytime they face the symptoms and it instantly dissolves to start the action.

What are Oral Thin Films?
With the recent developments in research and technology, more viable oral dosage forms have been introduced, especially to assist in medication adherence in pediatrics, geriatric, bedridden, nauseous, or non-compliant patients. Various bioadhesive mucosal dosage forms have been developed, including adhesive tablets, gels, ointments, patches, and more recently – Oral Thin Films (OTFs). Oral thin film is categorized into Mouth Dissolving Film/Fast Disintegrating Film, Buccal Film, and Sublingual Film.

The mouth dissolving film is also known as fast dissolving film, quick-dissolving film, and rapid dissolving film.

It consists of a fast-dissolving polymeric film embedded with a drug that quickly hydrates and disintegrates when placed on the tongue to provide rapid local or systemic drug delivery without the need for water.

Fast Disintegrating Film dissolves or disintegrates quickly in the oral cavity, resulting in the solution or suspension without the need for water – in a matter of seconds.

In contrast to other existing, rapid dissolving dosage forms (which consist of lyophilized products), the rapid films can be produced with a manufacturing process that is competitive with the manufacturing costs of conventional tablets.

Why Oral Thin Films?
Oral thin film disintegrates fast in the mouth and assures accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water or dosage measuring. In addition, the oral thin film permits intra-oral absorption, thus bypassing first-pass effects in some cases.

Rizatriptan vs Sumatriptan
Rizatriptan and sumatriptan are selective 5-HT(1B/1D) receptor agonists for the acute treatment of migraine. For oral formulations, the time to maximum plasma concentration is reached earlier with Rizatriptan than with Sumatriptan (1 h versus 2-2.5 h) and Rizatriptan has greater bioavailability than Sumatriptan (45% versus 15%).

These pharmacological advantages translate into a faster onset of action and a better overall response for oral Rizatriptan versus oral Sumatriptan. The two drugs have been directly compared in randomized, double-blind, placebo-controlled clinical trials with patients suffering from moderate to severe migraine attacks.

Rizatriptan 10 mg was generally superior to Sumatriptan on a measure of time-to-pain-relief within 2h where pain relief was defined as a reduction of pain to mild or none (odds ratio for Rizatriptan versus Sumatriptan 100 mg = 1.21; odds ratios for Rizatriptan 10 mg versus Sumatriptan 50 mg = 1.14 and 1.10 in two studies).

International Headache Society recommended endpoint of the percentage of patients pain-free at 2 h (40% for Rizatriptan 10 mg, 33% for Sumatriptan 100 mg, and 35% for Sumatriptan 50 mg). Further advantages for Rizatriptan were seen on stringent outcome measures of the percentage of patients who were completely free of all symptoms at 2 h, patient satisfaction with medication at 2 h, and 24-h sustained pain-free response.

About ZIM Laboratories
ZIM Labs is an innovative drug delivery solution provider focusing on improving patient convenience and adherence to drug intake. We offer a range of technology-based drug delivery solutions and non-infringing proprietary manufacturing processes for the production and supply of innovative and differentiated generic pharmaceutical products to our customers globally. At ZIM Labs we provide our customers a comprehensive range of value-added solid dosage differentiated generic products in semi-finished and finished categories/formulations. These include granules, pellets (sustained, modified, extended-release), taste-masked powders, suspensions, tablets, capsules, and recently developed Oral Thin Films (OTF)

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Sensual Toys for Valentine’s Day

Valentine’s Day is just around the corner, and hopefully any men reading this who are part of a couple have already made plans and invested in some appropriate gifts. But even if the romantic dinner and other plans are all set, maybe there’s an area that hasn’t been investigated yet – such as sensual toys? Valentine’s Day can be a perfect time to explore some sensual toys with a mate – and they can also help to improve a guy’s sensual and male organ health by providing new exercise for his “love muscle.”

Many couples are already into sensual toys and may feel they have all they need in that area. But for those who still have room in their sensual toys chest, or for those just starting out exploring this exciting area of sensual activity, following are some toys they may wish to explore.

• Male organ ring. Start with the basics. For many men, a male organ ring is the go-to “first sensual toy” option. It’s simplicity itself: a ring which fits snugly around the member (or the base of the member and underneath the sacks, depending on the style purchased). Male organ rings impede the flow of blood from the manhood so a member can stay harder longer. They are made from many different materials, including rubber, metal and leather. Some rings come with “bumps” on them, which many women find pleasurable during coupling. Some rings also vibrate, which can be pleasurable for both the man and the woman. In addition, some rings are made with a vibrating “extension” that can more directly stimulate the woman.

• Finger vibrator. Manual stimulation, either before or after penetration, is key to the sensual lives of many couples. Men may want to explore the use of a finger vibrator, which many women find helps create a more intense release than stimulation by finger or hand alone.

• Manhood copier. If a man’s partner truly adores his member, perhaps she would like a copy of it for when he is unavailable? There are a number of DIY kits on the market that enable a man to make a mold of his own tumescent member and use liquid plastic to create a very personalized replica.

• Remote controlled vibrators and plugs. Many vibrators and vibrating posterior plugs now come with remote controls so a partner can determine the amount of stimulation. While this is an especially attractive option for couples who are into submission and domination, many couples who are perfectly happy with “plain vanilla” coupling also get a kick out of these toys – especially if each member of the couple is controlling the other’s vibratory rate.

• Double male organ replica. Many men have found pleasure through posterior stimulation in recent years, especially when their partner has demanded a “turnabout” for being on the receiving end of posterior play. A double male organ replica is designed for penetration of two people at one time, so a man can be stimulated in the posterior at the same time his female partner is pleasured in her female organ.

• Massage oils. Finally, sometimes a couple just wants a low tech accessory – such as simple massage oils. Gentle touches from a partner’s hand are made extra special with oils that add an extra layer of soothing.

Sensual toys aren’t all that a man may want to have handy on Valentine’s Day. A healthy, exuberant manhood is also nice, so he needs to be using a first class male organ health crème (health professionals recommend Man1 Man Oil, which is clinically proven mild and safe for skin) regularly. When making a selection, find a crème that contains both L-arginine and L-carnitine. The former is an amino acid that helps boost nitric oxide production, thereby better enabling male organ blood vessels to expand as needed. L-carnitine is another amino acid, one which helps to protect against loss of sensation in a member which is handled too roughly.

Visit http://www.menshealthfirst.com for additional information on most common manhood health issues, tips on improving male organ sensitivity and what to do to maintain a healthy member. John Dugan is a professional writer who specializes in men’s health issues and is an ongoing contributing writer to numerous websites.

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Top 8 Reasons That Makes LED Flashlights The Best Alternative For Emergency

With natural resources& renewable energy encountering the challenges of an ever-boosting global population, power conservation has come to the front line of several fervent discussions regarding how to sustain our very existence. Well, LED lights are extremely diverse from typical bulbs and here in this article we will discuss about some of the advantages of LED flashlights. So, let’s throw a glance:

• Led flashlights last longer since they’re more durable & dependable than typical flashlights. It’s more realistic to employ this sort of flashlight. Its dependability has been confirmed by several homeowners.

• Led flashlights may employ non-rechargeable batteries. This is mainly gainful for those who utilize flashlight at regular intervals. Nonetheless, if the flashlight is to be required frequently, it can have rechargeable batteries so that there’s no require to buy substitute batteries every now and then.

• Sometimes called as mini flashlights, LED flashlights release a dazzling white light which’s most useful throughout the stormy climate when there is a power-cut. Furthermore, it can be employed throughout overnight camping & hiking trips.

• Led flashlights will save cash since they don’t require as much power as do typical flashlights. In fact, an LED bulb uses about fifty percent less energy in comparison to a standard light. It also needs smaller batteries. This sort of flashlight can survive for about 50,000 hours.

• A flashlight driven by LED technology can provide lighting up to sixty hours. Therefore, LEDs are considered as the best flashlight option, especially when it comes to emergency.

• LED flashlights are usually lighter in comparison to the typical flashlight since they don’t require big batteries. The 1st flashlight employing LED technology was invented in 1999. However, today with the improvement of technology, this sort of flashlight has turned out to be more affordable than ever before.

• Led driven flashlights are also power-efficient since they employs less energy to run. They often avails with rechargeable batteries, hence they’re more eco-friendly than the conventional flashlight.

• A flashlight driven by LED technology also discharge extremely bright illumination. The white light technology generate lighting which’s 6 times brighter in comparison to typical flashlight bulbs. Even if the battery and bulb begin to run low, the lighting will stay bright even with frequent use.

These reasons to pick LED flashlights shows that not just do LED lights save power, they’re also the most dependable emergency devices and superior in quality in comparison to their more energy-wasting, expensive counterpart – the typical flashlight.

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