Even after years of research, Migraine remains to be an incurable disorder – no treatment can make patients free of migraine permanently.

People suffering from migraines can keep their condition in control by avoiding triggers that cause migraine. Identifying these triggers and working towards making little changes in lifestyle like easing stress and having good sleep habits can help curb the symptoms.

Prompt action and timely treatment help patients return to their normal routine, decreasing the need for pain medication.

Having said that, there are medications that help prevent or stop migraines, keeping the symptoms from getting worse. Rizatriptan is one such medication.

What is Rizatriptan?
Rizatriptan is a medication that’s used to treat migraines. It belongs to a class of drugs known as triptans and helps relieve headache, pain, and other migraine symptoms caused due to nausea, vomiting, and sensitivity to light/sound.

It affects a certain natural substance (serotonin) that causes the narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain.

Understanding Migraine & its effects on the brain
Migraine is a chronic neurological disorder characterized by recurrent headaches that range from moderate to severe, often in association with a number of autonomic nervous system symptoms.

Approximately 15% of the world population is affected by migraine at some point in life. In basilar migraine, a patient will experience neurological symptoms related to the brain stem or with neurological symptoms on both sides of the body. Some common effects of this migraine include a sense of the world spinning, light-headedness, and confusion. Nausea occurs in almost 90% of people, and vomiting occurs in about one-third.

Other symptoms may include blurred vision, nasal stuffiness, diarrhea, frequent urination, pallor, or sweating. Moreover, swelling or tenderness of the scalp may occur as well as neck stiffness. Oftentimes, a feeling of pins-and-needles begins on one side in the hand and arm and spreads to the nose-mouth area on the same side. Numbness usually occurs after the tingling has passed, with a loss of position sense.

As Rizatriptan is an Oral Thin Film (also called Orally Dissolving Film), it becomes extremely convenient for the patient to take the required prescribed dosage even when suffering from such severe symptoms. It’s also very easy to carry and needs no water, unlike solid oral dosage – a patient can put this film in their mouth anywhere, anytime they face the symptoms and it instantly dissolves to start the action.

What are Oral Thin Films?
With the recent developments in research and technology, more viable oral dosage forms have been introduced, especially to assist in medication adherence in pediatrics, geriatric, bedridden, nauseous, or non-compliant patients. Various bioadhesive mucosal dosage forms have been developed, including adhesive tablets, gels, ointments, patches, and more recently – Oral Thin Films (OTFs). Oral thin film is categorized into Mouth Dissolving Film/Fast Disintegrating Film, Buccal Film, and Sublingual Film.

The mouth dissolving film is also known as fast dissolving film, quick-dissolving film, and rapid dissolving film.

It consists of a fast-dissolving polymeric film embedded with a drug that quickly hydrates and disintegrates when placed on the tongue to provide rapid local or systemic drug delivery without the need for water.

Fast Disintegrating Film dissolves or disintegrates quickly in the oral cavity, resulting in the solution or suspension without the need for water – in a matter of seconds.

In contrast to other existing, rapid dissolving dosage forms (which consist of lyophilized products), the rapid films can be produced with a manufacturing process that is competitive with the manufacturing costs of conventional tablets.

Why Oral Thin Films?
Oral thin film disintegrates fast in the mouth and assures accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water or dosage measuring. In addition, the oral thin film permits intra-oral absorption, thus bypassing first-pass effects in some cases.

Rizatriptan vs Sumatriptan
Rizatriptan and sumatriptan are selective 5-HT(1B/1D) receptor agonists for the acute treatment of migraine. For oral formulations, the time to maximum plasma concentration is reached earlier with Rizatriptan than with Sumatriptan (1 h versus 2-2.5 h) and Rizatriptan has greater bioavailability than Sumatriptan (45% versus 15%).

These pharmacological advantages translate into a faster onset of action and a better overall response for oral Rizatriptan versus oral Sumatriptan. The two drugs have been directly compared in randomized, double-blind, placebo-controlled clinical trials with patients suffering from moderate to severe migraine attacks.

Rizatriptan 10 mg was generally superior to Sumatriptan on a measure of time-to-pain-relief within 2h where pain relief was defined as a reduction of pain to mild or none (odds ratio for Rizatriptan versus Sumatriptan 100 mg = 1.21; odds ratios for Rizatriptan 10 mg versus Sumatriptan 50 mg = 1.14 and 1.10 in two studies).

International Headache Society recommended endpoint of the percentage of patients pain-free at 2 h (40% for Rizatriptan 10 mg, 33% for Sumatriptan 100 mg, and 35% for Sumatriptan 50 mg). Further advantages for Rizatriptan were seen on stringent outcome measures of the percentage of patients who were completely free of all symptoms at 2 h, patient satisfaction with medication at 2 h, and 24-h sustained pain-free response.

About ZIM Laboratories
ZIM Labs is an innovative drug delivery solution provider focusing on improving patient convenience and adherence to drug intake. We offer a range of technology-based drug delivery solutions and non-infringing proprietary manufacturing processes for the production and supply of innovative and differentiated generic pharmaceutical products to our customers globally. At ZIM Labs we provide our customers a comprehensive range of value-added solid dosage differentiated generic products in semi-finished and finished categories/formulations. These include granules, pellets (sustained, modified, extended-release), taste-masked powders, suspensions, tablets, capsules, and recently developed Oral Thin Films (OTF)

Inflammatory Bowel Disease (IBD) is a broad term that represents a group of intestinal disorders that cause prolonged inflammation of the digestive tract. The two most common inflammatory bowel diseases are ulcerative colitis and Crohn’s disease.

Dr. Vikrant Kale has successfully completed Fellowship in Inflammatory bowel disease (IBD) from Oxford University (UK) in 2018 and has experience in treating various IBD diseases such as ulcerative colitis and Crohn’s disease. These things make an IBD Specialist in Pune or Crohn’s & Colitis specialist in Pune. If you have to face any problem with IBD Disease then you must visit Dr. Vikrant Kale for expert advice.

What are the types of IBD?
Crohn’s disease and ulcerative colitis are the main types of IBD. Types include:

Crohn’s disease: Crohn’s disease can affect any part of the digestive tract between the mouth and the anus. However, it most commonly develops in the final section of the small intestine and colon. They also suggest that Crohn’s disease is most likely to develop when a person is aged 20–29
Ulcerative colitis: This condition causes inflammation in the large intestine or colon.
Microscopic colitis causes intestinal inflammation that’s only detectable with a microscope.
What are the symptoms of IBD?
inflammation and where it occurs. Crohn’s disease and ulcerative colitis cause similar symptoms. some common symptoms are:

Persistent diarrhea
Abdominal pain
Rectal bleeding/bloody stools
Weight loss
Rarely, IBD may also cause:

Fatigue
Fever
Itchy, red, painful eyes
Joint pain
Nausea and vomiting
Skin rashes and sores (ulcers)
Vision problems
If you notice the above symptoms then you must visit the IBD Specialist Gastroenterologist in Pune because People with IBD have a higher risk of developing colon (colorectal) cancer.

How is IBD diagnosed?
The Diagnosis process of IBD is important because Crohn’s disease and ulcerative colitis cause similar symptoms due to this accurate diagnosis are very important. Dr. Vikrant Kale IBD Specialist in Pune who diagnose patient with below test such asYou may also get one or more of these diagnostic tests:

Colonoscopy: It is used to examine the large and small intestines.
EUS (endoscopic ultrasound): It is used to check the digestive tract for swelling and ulcers.
Flexible sigmoidoscopy: It is used to examine the inside of the rectum and anus.
Imaging scan: These tests include CT scan or MRI
Upper endoscopy: It helps to examine the digestive tract from the mouth to the start of the small intestine.
IBD Treatment in Pune:
Dr. Vikrant Kale provides the best treatment for IBD disease in Pune The most common treatments for IBD are medications and surgery, which the sections below will discuss in more detail.

Medication: Medications can help control inflammation so you don’t have symptoms
Surgery: Surgery is needed when medications no longer provide symptom relief. As per Data 7 in 10 people with Crohn’s disease eventually need surgery and after 30+ years of living with ulcerative colitis, about 1 in 3 people need surgery.
How can I prevent inflammatory bowel disease (IBD)?
While there isn’t anything you can do to prevent IBD, certain dietary and lifestyle changes may control the symptoms. You can:

Eat smaller meals every two to four hours.
Find healthy ways to manage stress, such as meditation.
Get plenty of sleep and stay physically active.
Keep a food diary to identify foods that trigger IBD flares.
Reduce foods that irritate the intestines.
How to Book Appointment With IBD Specialist in Pune :
In Pune, most gastroenterologists treat IBD disease but Dr. Vikrant Kale is a gastroenterologist in Pune who can successfully complete Fellowship in Inflammatory bowel disease (IBD) and Upper & Lower GI Endoscopy from Oxford University (UK) in 2018. Also, his special interests are in Inflammatory bowel disease (Ulcerative colitis, Crohn’s disease, Microscopic colitis) treatment. Also, He has done around 3000 gastroscopies, 2000 colonoscopies, and 700 ERCPs until now. These make him one of the best IBD Specialists in Pune. For more information about our comprehensive treatment options, or to request an appointment with the best Gastroentrologist in Pune call 07558423708 or Click on Book Appointment for online booking with your near hospital

Saving your marriage is kind of you are going to adopt the changes. Are you ready to change? If your answer is yes then you should read this. Changes happen for goods. For a stronger, healthier, and happier relationship things have to change between you and your partner. Here are some top ways that you can adapt to save your marriage.

1. Accept that you are not a perfect wife or husband. Accepting helps to slow down things and you will get the time to think and process your situation. Work for the perfections.

2. Start adding a little joy to your daily life schedule. Remind each other their good habits besides the things that upset you or take you away from your marriage.

3. Marriage is a type of mutual understanding. Try to understand each other if there happen disputes then work on that and find a resolution or a common ground where you both agree mutually.

4. complaining is kind of the big mistake people make in a relationship. In marriages, people often misunderstood complaining. As we know there is always a hidden message in complain, If you love your partner and wants to save your marriage then process his/her complaint and find the hidden message inside or simply ask.

5. Sometimes you need to compromise in a marriage. Both you and your spouse should be ready to make some adjustments for the other. Compromise saves a lot of marriages.

6. Don’t stop dating as you do at the start. Don’t let the romance die in between of respectability. Plan outdoor activity and you don’t need to alone take your kids or other members but being together for some time will help you to make a strong bond.

Hope all these points will help you to save your marriage. If you think you are not in the position to save your marriage or a relationship then you should connect with a marriage counselor. With the help of marriage counseling, you can save your relationship.

Importance of Selecting a Qualified Rhinoplasty Surgeon
The nose, being a central feature of the face, significantly influences one’s appearance and self-esteem. An expertly performed rhinoplasty can enhance facial harmony and boost confidence, while a poorly executed procedure can lead to dissatisfaction and the need for corrective surgeries.

Key Considerations When Choosing Your Surgeon
1. Gather Recommendations
Start by compiling a list of potential surgeons through referrals from friends, family, and healthcare professionals who have had positive experiences.

2. Verify Credentials and Experience
Ensure the surgeon is board-certified in plastic surgery or otolaryngology with a subspecialty in facial plastic surgery. According to the American Board of Plastic Surgery, board certification ensures that the surgeon has completed rigorous exams and meets high standards in the specialty. Research their years of practice and the number of rhinoplasty procedures performed. Experience plays a pivotal role as it correlates with the surgeon’s proficiency and familiarity with various nasal types and structures.

3. Consult Previous Patients
Speaking with former patients provides insights into their satisfaction with the results and the surgeon’s care throughout the process. This firsthand feedback is invaluable.

4. Schedule a Consultation
A personal consultation helps assess the surgeon’s communication style, understanding of your aesthetic goals, and their ability to provide a realistic outlook on the outcomes. During this meeting, consider asking:

How many rhinoplasty surgeries have you performed?
Can I see before-and-after photos of your previous patients?
What is your policy on revision surgeries if I’m dissatisfied with the results?
Questions to Ask Your Surgeon
Credentials and Certifications: Confirm their educational background, training, and certifications. A lack of online presence or transparency can be a red flag.
Experience with Rhinoplasty Procedures: Experienced surgeons typically have performed hundreds to thousands of surgeries, refining their techniques over time. For instance, a study by the National Institutes of Health suggests that surgeons with extensive experience in rhinoplasty are more likely to achieve optimal results.
Visual Proof of Success: Request a gallery of before-and-after photos of actual patients. Avoid surgeons who only show stock images or are hesitant to provide these details.
Patient Testimonials: Ask for references or testimonials from previous clients to gauge their satisfaction with the surgical outcomes and their overall experience.
Financial Considerations and Insurance
While cosmetic rhinoplasty is generally not covered by insurance, procedures correcting functional issues might be eligible for coverage. It’s crucial to verify this with your insurance provider and choose a surgeon within your network to minimize out-of-pocket costs. Remember, the cost should not be the sole deciding factor; the surgeon’s skill and your comfort with them are paramount.

Conclusion
Choosing the right rhinoplasty surgeon involves thorough research and careful consideration of their credentials, experience, and patient satisfaction. By taking these steps, you can increase your chances of a successful outcome that enhances your appearance and confidence.

For further guidance on selecting a top-tier rhinoplasty surgeon in India, consider consulting resources like the Best Rhinoplasty Surgery in India or visiting established medical platforms that provide detailed profiles of qualified surgeons.